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Online Monitoring of Intelligent Polymers for Drug Release with Hyperpolarized Xenon
Author(s) -
Glöggler Stefan,
Raue Markus,
Colell Johannes,
Türschmann Pierre,
Liebisch Alexander,
Mang Thomas,
Blümich Bernhard,
Appelt Stephan
Publication year - 2012
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201200658
Subject(s) - xenon , polymer , drug , chemistry , materials science , nanotechnology , chemical engineering , organic chemistry , pharmacology , medicine , engineering
Welcome to the guest zone: By combining hyperpolarized xenon and simple low‐field NMR devices it is possible to obtain more control over hydrogels that show potential as drug delivery systems. An alternative way of polymer swelling‐degree determination is demonstrated with real‐time NMR analysis. An ideal region for solvent uptake can be defined in which the absorbed solvent molecules are completely confined in the nano‐porous network of the hydrogel.