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Unfolding a Photoswitchable Azo‐Foldamer Reveals a Non‐Covalent Reaction Mechanism
Author(s) -
Braun Sebastian,
Böckmann Marcus,
Marx Dominik
Publication year - 2012
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201101001
Subject(s) - foldamer , azobenzene , covalent bond , chemistry , dynamic covalent chemistry , reaction mechanism , molecular switch , supramolecular chemistry , photochemistry , molecule , stereochemistry , organic chemistry , catalysis
Simulations on photoswitching of an azobenzene‐functionalized helical m PE foldamer (see picture) reveal several distinct non‐covalent reaction channels. It is expected that distinct products can be selectively (de)stabilized by attaching suitable side chains to the backbone. The methodology presented could be applied to study photoinduced manipulation of AB‐functionalized proteins.