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Mechanism of Action of Cyclic Oligosquaramides on DPPC Phospholipid Monolayers
Author(s) -
GinerCasares Juan J.,
Keller Janos,
Rotger Carmen,
Costa Antoni,
Brezesinski Gerald
Publication year - 2012
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201100666
Subject(s) - squaramide , monolayer , moiety , phospholipid , chemistry , mechanism of action , biological membrane , membrane , stereochemistry , derivative (finance) , combinatorial chemistry , organic chemistry , biochemistry , enantioselective synthesis , organocatalysis , economics , financial economics , in vitro , catalysis
New moiety for drug design: The chemical group squaramide shows promising results in medicinal chemistry. The mechanism of action of cyclic oligosquaramides at biological membranes is revealed by a monolayer study. The biological activity is related to the hydrophobicity of the new squaramide‐derivative drugs.