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MQD—Multiplex‐Quadrature Detection in Multi‐Dimensional NMR
Author(s) -
Schlagnitweit Judith,
Horničáková Michaela,
Zuckerstätter Gerhard,
Müller Norbert
Publication year - 2012
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201100525
Subject(s) - quadrature (astronomy) , heteronuclear molecule , multiplex , analytical chemistry (journal) , sensitivity (control systems) , spectral line , coherence (philosophical gambling strategy) , resolution (logic) , chemistry , algorithm , physics , mathematics , materials science , computational physics , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , chromatography , optics , computer science , electronic engineering , statistics , engineering , artificial intelligence , bioinformatics , astronomy , biology
With multiplex‐quadrature detection (MQD) the tasks of coherence selection and quadrature separation in N ‐dimensional heteronuclear NMR experiments are merged. Thus the number of acquisitions required to achieve a desired resolution in the indirect dimensions is significantly reduced. The minimum number of transients per indirect data point, which have to be combined to give pure‐phase spectra, is thus decreased by a factor (3/4) N −1 . This reduction is achieved without adjustable parameters. We demonstrate the advantage by MQD 3D HNCO and HCCH‐TOCSY spectra affording the same resolution and the same per‐scan sensitivity as standard phase‐cycled ones, but obtained in only 56 % of the usual time and by resolution improvements achieved in the same amount of time.