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NMR and MRI of Blood‐Dissolved Hyperpolarized Xe‐129 in Different Hollow‐Fiber Membranes
Author(s) -
Amor Nadia,
Hamilton Kathrin,
Küppers Markus,
Steinseifer Ulrich,
Appelt Stephan,
Blümich Bernhard,
SchmitzRode Thomas
Publication year - 2011
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201100446
Subject(s) - membrane , hollow fiber membrane , fiber , dissolution , chemistry , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , xenon , bubble , analytical chemistry (journal) , materials science , chromatography , organic chemistry , parallel computing , computer science , biochemistry , physics
Magnetic resonance of hyperpolarized 129 Xe has found a wide field of applications in the analysis of biologically relevant fluids. Recently, it has been shown that the dissolution of hyperpolarized gas into the fluid via hollow‐fiber membranes leads to bubble‐free 129 Xe augmentation, and thus to an enhanced signal. In addition, hollow‐fiber membranes permit a continuous operation mode. Herein, a quantitative magnetic resonance imaging and spectroscopy analysis of a customized hollow‐fiber membrane module is presented. Different commercial hollow‐fiber membrane types are compared with regard to their 129 Xe dissolution efficiency into porcine blood, its constituents, and other fluids. The presented study gives new insight into the suitability of these hollow‐fiber membrane types for hyperpolarized gas dissolution setups.