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Sub‐Diffraction Imaging of Huntingtin Protein Aggregates by Fluorescence Blink‐Microscopy and Atomic Force Microscopy
Author(s) -
Duim Whitney C.,
Chen Bryan,
Frydman Judith,
Moerner W. E.
Publication year - 2011
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201100392
Subject(s) - microscopy , fluorescence microscope , atomic force microscopy , fluorescence , diffraction , chemistry , resolution (logic) , huntingtin , materials science , biophysics , nanotechnology , crystallography , optics , physics , biology , artificial intelligence , computer science , biochemistry , mutant , gene
Resolving aggregates: Single‐molecule super‐resolution imaging of fluorescent Huntington′s disease proteins reveals the detailed morphology of aggregates in aqueous environments (see figure, color) and shows excellent agreement with atomic force microscopy images (figure, black) of the same aggregates.