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Molecular Recognition Force Spectroscopy Study of the Specific Lectin and Carbohydrate Interaction in a Living Cell
Author(s) -
Li Yongjun,
Wang Jine,
Xing Chunyan,
Wang Zhenxin,
Wang Hongda,
Zhang Bailin,
Tang Jilin
Publication year - 2011
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201001008
Subject(s) - force spectroscopy , lectin , living cell , chemistry , carbohydrate , molecular recognition , hela , spectroscopy , molecular dynamics , molecule , biophysics , biochemistry , cell , computational chemistry , biology , biological system , organic chemistry , physics , quantum mechanics
Molecular recognition force spectroscopy is used to study the specific interaction between RCA 120 and Gal on living HeLa cells at the single‐molecule level (see picture). The results indicate that this technique can be used to explore the force and dynamics of lectin–carbohydrate interaction in living cells in their native environments.