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On the Compatibility Criteria for Protein Encapsulation inside Mesoporous Materials
Author(s) -
Giussani Lara,
Fois Ettore,
Gianotti Enrica,
Tabacchi Gloria,
Gamba Aldo,
Coluccia Salvatore
Publication year - 2010
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200901038
Subject(s) - encapsulation (networking) , compatibility (geochemistry) , mesoporous material , materials science , nanotechnology , mesoporous organosilica , mesoporous silica , aqueous solution , chemistry , chemical engineering , computer science , organic chemistry , composite material , catalysis , computer network , engineering
The properties of the enzyme pepsin, relevant to its incorporation inside the channels of mesoporous silica materials in the preparation of bioinorganic hybrids, are highlighted by molecular dynamics simulations of aqueous solutions of the protein under conditions optimal for encapsulation in SBA‐15. The protein size, shape, flexibility and surface properties are calculated with the aim of deriving general accessibility/compatibility criteria favouring encapsulation inside mesoporous systems.