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Targeting Non‐Fluorescent Molecules by Nonlinear Optical Imaging
Author(s) -
Haran Gilad
Publication year - 2010
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200900979
Subject(s) - fluorescence , nonlinear optics , nonlinear system , nonlinear optical , molecule , optical imaging , molecular imaging , nanotechnology , fluorescence lifetime imaging microscopy , optics , chemistry , materials science , biophysics , physics , biology , organic chemistry , quantum mechanics , microbiology and biotechnology , in vivo
Nonlinear optics to the rescue: Fluorescence‐based methods provide powerful means for imaging biological samples (see picture) with molecular specificity. But what if the molecule‐of‐choice, such as hemoglobin, is non‐fluorescent? Novel applications of nonlinear optics provide solutions.