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Diffusion of Circular DNA in Two‐Dimensional Cavity Arrays
Author(s) -
Nykypanchuk Dmytro,
Hoagland David A.,
Strey Helmut H.
Publication year - 2009
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200900655
Subject(s) - dna , circular dna , diffusion , chemical physics , molecule , polymer , chemistry , crystallography , fluorescence , molecular physics , nanotechnology , materials science , biophysics , optics , physics , thermodynamics , biology , biochemistry , organic chemistry , genome , gene
Through a two‐dimensional cavity array with connecting pores of submolecular size, diffusion of relaxed circular and linear DNA molecules is visualized by fluorescence microscopy. Across the entropic barriers transport regime, associated with spatially heterogeneous confinement of flexible polymers, circular DNA diffuses slower than linear DNA of the same length, a trend indicating that linear DNA preferably moves through connecting pores by the threading of an end rather than the looping of a midsection.