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Determining the Zero‐Force Binding Energetics of an Intercalated DNA Complex by a Single‐Molecule Approach
Author(s) -
Yang TzuSen,
Cui Yujia,
Wu ChienMing,
Lo JemMau,
Chiang ChiShiun,
Shu WunYi,
Chung WeiJu,
Yu ChungShan,
Chiang KuoNing,
Hsu Ian C.
Publication year - 2009
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200900435
Subject(s) - intercalation (chemistry) , dna , energetics , zero (linguistics) , binding energy , molecule , chemistry , crystallography , physics , thermodynamics , biochemistry , quantum mechanics , philosophy , linguistics , organic chemistry , inorganic chemistry
Binding behavior of DNA : A wormlike chain model is applied to determine the zero‐force binding energetics of an intercalated DNA complex. A mono‐intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.