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The Dynamic Side of the Hofmeister Effect: A Single‐Molecule Nanopore Study of Specific Complex Formation
Author(s) -
Gurnev Philip A.,
Harries Daniel,
Parsegian V. Adrian,
Bezrukov Sergey M.
Publication year - 2009
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200900312
Subject(s) - nanopore , chemistry , carboxylate , kinetics , adamantane , molecule , salt (chemistry) , dynamic equilibrium , computational chemistry , chemical physics , nanotechnology , organic chemistry , materials science , physics , quantum mechanics
Beyond measurements of equilibria: An α‐hemolysin nanopore is used as a single‐molecule sensor to follow the effects of different salts on the complexation reaction of γ‐cyclodextrin and adamantane carboxylate (see picture). The kinetics underlying the dynamic equilibrium are studied to reveal qualitatively different dynamic actions of various cosolute salts.