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Topography and Recognition Imaging of Protein‐Patterned Surfaces Generated by AFM Nanolithography
Author(s) -
Zhu Rong,
Ebner Andreas,
Kastner Markus,
Preiner Johannes,
Howorka Stefan,
Hinterdorfer Peter
Publication year - 2009
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200900245
Subject(s) - nanolithography , streptavidin , nanoscopic scale , biotinylation , atomic force microscopy , nanotechnology , bovine serum albumin , materials science , dip pen nanolithography , molecular biophysics , chemistry , fabrication , chromatography , biochemistry , biotin , medicine , alternative medicine , pathology
Abstract Native‐protein nanolithography is combined with topography and recognition imaging to synergistically use AFM tips to write and image nanoscale protein patterns on a surface (see picture). The approach is validated with different feedback modes, using surface‐bound biotinylated bovine serum albumin (BSA) protein and AFM tips carrying streptavidin.