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Cover Picture: Progress in Hyperpolarized Ultrafast 2D NMR Spectroscopy (ChemPhysChem 16/2008)
Author(s) -
Mishkovsky Mor,
Frydman Lucio
Publication year - 2008
Publication title -
chemphyschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200890064
Subject(s) - heteronuclear molecule , hyperpolarization (physics) , protonation , chemistry , nuclear magnetic resonance spectroscopy , ultrashort pulse , two dimensional nuclear magnetic resonance spectroscopy , molecule , spectroscopy , nuclear magnetic resonance , analytical chemistry (journal) , optics , stereochemistry , physics , laser , ion , organic chemistry , quantum mechanics
The cover picture illustrates the benefits that result from combining ex situ dynamic nuclear polarization (DNP) with "ultrafast" 2D NMR. In their article on page 2340, M. Mishkovsky and L. Frydman show that the single‐scan nature of the latter approach makes good use of the sensitivity enhancement afforded by the hyperpolarization procedure, which in the case of small molecules often exceeds 1,000. 2D heteronuclear correlation spectra correlating the non‐protonated 13 C sites with nearby protons—methyls for the indicated molecules—can thus be collected in negligible amounts of spectrometer time (1 scan vs 2048 scans) and at considerably lower final concentrations (0.2 m m vs 20 m m) than upon using conventional counterparts.