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Binding of DNA Nucleobases and Nucleosides with Graphene
Author(s) -
Varghese Neenu,
Mogera Umesha,
Govindaraj Achutharao,
Das Anindya,
Maiti Prabal K.,
Sood Ajay K.,
Rao C. N. R.
Publication year - 2009
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200800459
Subject(s) - nucleobase , thymine , isothermal titration calorimetry , chemistry , guanine , van der waals force , graphene , solvation , cytosine , dna , computational chemistry , crystallography , molecule , nanotechnology , nucleotide , materials science , organic chemistry , biochemistry , gene
Interaction of two different samples of graphene with DNA nucleobases and nucleosides is investigated by isothermal titration calorimetry. The relative interaction energies of the nucleobases decrease in the order guanine (G)>adenine (A)>cytosine (C)>thymine (T) in aqueous solutions, although the positions of C and T seem to be interchangeable. The same trend is found with the nucleosides. Interaction energies of the A–T and G–C pairs are somewhere between those of the constituent bases. Theoretical calculations including van der Waals interaction and solvation energies give the trend G>A∼T>C. The magnitudes of the interaction energies of the nucleobases with graphene are similar to those found with single‐walled carbon nanotubes.