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Quantitative Online Detection of Low‐Concentrated Drugs via a SERS Microfluidic System
Author(s) -
Ackermann Katrin R.,
Henkel Thomas,
Popp Jürgen
Publication year - 2007
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200700554
Subject(s) - microfluidics , phenothiazine , nanotechnology , raman scattering , colloid , materials science , nanoparticle , dynamic light scattering , drug delivery , drug detection , bioanalysis , chemistry , chromatography , raman spectroscopy , optics , medicine , physics , pharmacology
Herein, quantitative online monitoring of concentration fluctuations of different interesting drugs, namely, the phenothiazine promethazine as well as the anti‐cancer agent mitoxantrone via surface enhanced Raman scattering assay based on a microfluidic device is demonstrated. With the applied liquid/liquid two‐phase‐segmented flow system we succeed in preventing the adhesion of nanoparticle aggregates to the channel walls which is necessary for a quantitative analysis. Even after repeated cycles no carry‐over due to sedimentation of colloid particles is observed. To the best of our knowledge these are the first measurements applying a combination of a microfluidic device with SERS detection for quantitative online monitoring of fluctuations in drug concentrations over hours without use of aggressive chemicals for rinsing the chip surfaces prior to each measurement.