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In Situ and On‐Line Monitoring of Hydrodynamic Flow Profiles in Microfluidic Channels Based on Microelectrochemistry: Optimization of Channel Geometrical Parameters for Best Performance of Flow Profile Reconstruction
Author(s) -
Amatore Christian,
Klymenko Oleksiy V.,
Oleinick Alexander,
Svir Irina
Publication year - 2007
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200700297
Subject(s) - microfluidics , flow (mathematics) , channel (broadcasting) , in situ , materials science , line (geometry) , chemistry , nanotechnology , analytical chemistry (journal) , mechanics , chromatography , computer science , physics , telecommunications , geometry , mathematics , organic chemistry
Abstract A theoretical approach for flow profile reconstruction in a rectangular microfluidic channel equipped with one or two microband electrodes working in generator–collector and generator–generator regimes was proposed by us previously ( ChemPhysChem 2005 , 6 , 1581–1589; ChemPhysChem 2006 , 7 , 482–487). The purpose of the current study is to determine the ranges of dimensionless parameters corresponding to the highest sensitivity of the minimized functional to the shape of the flow profile. By application of a cubic spline to approximate the flow profile and analysis of the least‐squares functional, which can then be represented as a function of one variable, we derive the area of optimal method performance. Thus, mathematical confirmation of our previous theoretical physical predictions could be obtained.