Premium
Collapsed But Not Folded: Looking with Advanced Optical Spectroscopy at Protein Folding
Author(s) -
Enderlein Jörg
Publication year - 2007
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200700247
Subject(s) - protein folding , folding (dsp implementation) , native state , unfolded protein response , crystallography , chemistry , chemical physics , phi value analysis , folding funnel , spectroscopy , nanotechnology , downhill folding , materials science , physics , biochemistry , endoplasmic reticulum , engineering , electrical engineering , quantum mechanics
The intermediate folding step : The highlight discusses a recent study by Hoffman et al. on the collapsed but still unfolded state of a small protein under close to native conditions. This collapsed unfolded state (see picture) is an important intermediate between the completely denatured, unfolded and the completely folded, native protein structure and is thought to be of paramount importance for the final folding.