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Selective Solvation of Cyclodextrins by Small Molecules: A NOE Study
Author(s) -
GuerreroMartínez Andrés,
Berger Stefan,
Tardajos Gloria
Publication year - 2006
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200600314
Subject(s) - solvation , heteronuclear molecule , chemistry , nuclear overhauser effect , intermolecular force , molecule , cyclodextrin , solvent , solvent effects , computational chemistry , chemical physics , organic chemistry
A study of the solvation state of α‐ cyclodextrin (α‐CD) in water and in a water–trifluoroethanol (TFE) mixture is carried out by measuring homo‐ and heteronuclear intermolecular NOE (nuclear Overhauser effect) enhancements. The results give evidence of the site specificity of CD regions in solute–solvent interactions as a consequence of an internal complexation, which can be explained by the different hydrophobicity patterns of the CDs (see figure).