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Protein Amyloidogenesis in the Context of Volume Fluctuations: A Case Study on Insulin
Author(s) -
Smirnovas Vytautas,
Winter Roland,
Funck Theodor,
Dzwolak Wojciech
Publication year - 2006
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200500717
Subject(s) - compressibility , chemistry , context (archaeology) , calorimetry , thermodynamics , isothermal titration calorimetry , insulin , physics , medicine , paleontology , biology
Unfolding and aggregation of insulin: Using ultrasound velocimetry, densimetry and pressure‐perturbation calorimetry, the authors provide a precise description of the time‐dependent aggregation process in insulin (see figure). Changes in the thermodymanic properties such as the coefficient of thermal expansion α and isothermal compressibility β T of the protein highlight the importance of volume fluctuations during the unfolding and fibrillation process.