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Carriers versus Adapters in Stochastic Sensing
Author(s) -
Braha Orit,
Webb Jadon,
Gu LiQun,
Kim Kimoon,
Bayley Hagan
Publication year - 2005
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200400595
Subject(s) - tetrahydrofuran , analyte , dissociation (chemistry) , dissociation constant , molecule , chemistry , organic chemistry , biochemistry , receptor , solvent
The perfect host : The detection of analyte‐dependent changes in the conduction of individual transmembrane protein pores is demonstrated for small organic molecules, which are detected as complexes with a carrier molecule, cucurbit[6]uril (CB6). The carrier system also allows the determination of dissociation constants, and association and dissociation rate constants, for CB6⋅guest pairs (see picture; αHL=α‐hemolysin, THF=tetrahydrofuran).
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