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The Effect of Molecular Organisation in DNA Oligomers Studied by Femtosecond Fluorescence Spectroscopy
Author(s) -
Markovitsi Dimitra,
Sharonov Alexei,
Onidas Delphine,
Gustavsson Thomas
Publication year - 2003
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200390050
Subject(s) - femtosecond , fluorescence , femtochemistry , fluorescence spectroscopy , dna , chemistry , spectroscopy , photochemistry , reactivity (psychology) , nucleotide , excited state , helix (gastropod) , chemical physics , biochemistry , optics , biology , physics , atomic physics , laser , quantum mechanics , medicine , ecology , alternative medicine , pathology , snail , gene
Organisation lengthens life! The first fluorescence investigation of DNA oligomers performed with femtosecond resolution revealed that organisation of nucleotides into single strands, and further into double strands, makes the fluorescence decays slower and slower (see graph). This is important because a longer lifetime increases the reactivity of the excited states and, thus, the probability of inducing damage to the double helix.