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Pressure Perturbation Calorimetry: A New Technique Provides Surprising Results on the Effects of Co‐solvents on Protein Solvation and Unfolding Behaviour
Author(s) -
Ravindra Revanur,
Winter Roland
Publication year - 2004
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200301080
Subject(s) - solvation , calorimetry , chemistry , solvent , chemical physics , thermodynamics , solvation shell , implicit solvation , computational chemistry , organic chemistry , physics
Exquisitely sensitive , pressure perturbation calorimetry was used by the authors to study the solvation and volumetric properties of proteins in their native and unfolded states. The magnitude and even sign of the volume change on unfolding drastically depends on the co‐solvent concentration (see graphic).