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Transverse Dephasing Optimised NMR Spectroscopy in Solids: Natural‐Abundance 13 C Correlation Spectra
Author(s) -
De Paëpe Gaël,
Lesage Anne,
Steuernagel Stefan,
Emsley Lyndon
Publication year - 2004
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200301062
Subject(s) - dephasing , heteronuclear molecule , chemistry , spectroscopy , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , spectral line , molecule , transverse relaxation optimized spectroscopy , coherence (philosophical gambling strategy) , nmr spectra database , solid state nuclear magnetic resonance , nuclear magnetic resonance , stereochemistry , fluorine 19 nmr , organic chemistry , physics , condensed matter physics , quantum mechanics , astronomy
The transverse dephasing optimized (TDOP) approach can be used to obtain heteronuclear decoupling sequences that increase significantly coherence lifetimes in solid‐state NMR spectroscopy, leading to a dramatic improvement in the sensitivity of correlation experiments. Herein we demonstrate experimentally on several model organic compounds that, by applying this procedure, solid‐state 13 C‐refocused INADEQUATE experiments are feasible at natural abundance on medium‐sized molecules. Examples are provided for powdered crystalline cholesteryl acetate as well as for a sample of brucine, a less ordered compound. Effects of molecular dynamics on the sensitivity of the experiment are also discussed for a sample of tyrosine ethyl ester.