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Conformers of Guanosines and their Vibrations in the Electronic Ground and Excited States, as Revealed by Double‐Resonance Spectroscopy and Ab Initio Calculations
Author(s) -
Nir Eyal,
Hünig Isabel,
Kleinermanns Karl,
de Vries Mattanjah S.
Publication year - 2004
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.200300862
Subject(s) - conformational isomerism , intramolecular force , chemistry , ab initio , spectroscopy , ab initio quantum chemistry methods , excited state , resonance (particle physics) , guanosine , hydrogen bond , nuclear magnetic resonance spectroscopy , resonance raman spectroscopy , computational chemistry , crystallography , photochemistry , raman spectroscopy , molecule , atomic physics , stereochemistry , organic chemistry , physics , biochemistry , optics , quantum mechanics
Strong intramolecular 5′‐OH⋅⋅⋅3‐N hydrogen bonds stabilize guanosine, 2′‐deoxyguanosine, and 3′‐deoxyguanosine and fold them into a single preferred conformation (see picture), even in the absence of solvent interactions or DNA backbones. This conclusion was reached by means of a study combining UV–UV and IR–UV double‐resonance laser spectroscopy and ab initio calculations.