Premium
Pharmacokinetics and Safety of PTC596, a Novel Tubulin‐Binding Agent, in Subjects With Advanced Solid Tumors
Author(s) -
Shapiro Geoffrey I.,
O'Mara Edward,
Laskin Oscar L.,
Gao Lan,
Baird John D.,
Spiegel Robert J.,
Kaushik Diksha,
Weetall Marla,
Colacino Joseph,
O'Keefe Kylie,
Branstrom Arthur,
Goodwin Elizabeth,
Infante Jeffrey,
Bedard Philippe L.,
Kong Ronald
Publication year - 2021
Publication title -
clinical pharmacology in drug development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.711
H-Index - 22
eISSN - 2160-7648
pISSN - 2160-763X
DOI - 10.1002/cpdd.904
Subject(s) - medicine , pharmacokinetics , neutropenia , nausea , vomiting , dosing , adverse effect , pharmacology , toxicity , gastroenterology
PTC596 is a novel, orally bioavailable, small‐molecule tubulin‐binding agent that reduces B‐cell–specific Moloney murine leukemia virus insertion site 1 activity and is being developed for the treatment of solid tumors. A phase 1, open‐label, multiple‐ascending‐dose study was conducted to evaluate the pharmacokinetics and safety of the drug in subjects with advanced solid tumors. PTC596 was administered orally biweekly based on body weight. Dose escalation followed a modified 3 + 3 scheme using doses of 0.65, 1.3, 2.6, 5.2, 7.0, and 10.4 mg/kg. Following oral administration, PTC596 was rapidly absorbed, and between 0.65 and 7.0 mg/kg reached a maximum plasma concentration 2 to 4 hours after dosing. Area under the plasma concentration–time curve increased proportionally with body weight–adjusted doses. Maximum plasma concentration increased with dose, although the increase was less than dose proportional at dose levels >2.6 mg/kg. No accumulation occurred after multiple administrations up to 7.0 mg/kg. PTC596 had a terminal half‐life ranging 12 to 15 hours at all doses except for the highest dose of 10.4 mg/kg, where the half‐life was approximately 20 hours. Overall, PTC596 was well tolerated. The most frequently reported PTC596‐related treatment‐emergent adverse events were mild to moderate gastrointestinal symptoms, including diarrhea (54.8%), nausea (45.2%), vomiting (35.5%), and fatigue (35.5%). Only 1 patient treated with 10.4 mg/kg experienced dose‐limiting toxicity of neutropenia and thrombocytopenia, both of which were reversible. Stable disease as best overall response was observed among 7 patients, with 2 patients receiving the study drug up to 16 weeks. These results support the further development of PTC596 for the treatment of solid tumors.