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A Thorough QTc Study Confirms Early Pharmacokinetics/QTc Modeling: A Supratherapeutic Dose of Omarigliptin, a Once‐Weekly DPP‐4 Inhibitor, Does Not Prolong the QTc Interval
Author(s) -
Tatosian Daniel A.,
Cardillo Marricco Nadia,
Glasgow Xiaoli Shirley,
DeGroot Bruce,
Dunnington Katherine,
George Laura,
Gendrano Isaias Noel,
JohnsonLevonas Amy O.,
Swearingen Dennis,
Kauh Eunkyung
Publication year - 2016
Publication title -
clinical pharmacology in drug development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.711
H-Index - 22
eISSN - 2160-7648
pISSN - 2160-763X
DOI - 10.1002/cpdd.260
Subject(s) - qt interval , medicine , pharmacokinetics , long qt syndrome , pharmacology , anesthesia
Omarigliptin is a dipeptidyl peptidase‐4 inhibitor being developed as a once‐weekly treatment for type 2 diabetes. This double‐blind, double‐dummy, randomized, 3‐period balanced crossover study definitively evaluated the effects of a supratherapeutic omarigliptin dose on QTc interval. Population‐specific correction of QT interval (QTcP) was used for the primary analysis. Healthy subjects (n = 60) were enrolled and received treatments separated by a ≥4‐week washout: (1) single‐dose 25 mg omarigliptin (day 1), single‐dose 175 mg omarigliptin (day 2); (2) placebo (day 1) followed by single‐dose 400 mg moxifloxacin (day 2); (3) placebo (days 1 and 2). Day 2 QTcP intervals were analyzed. The primary hypothesis was supported if the 90%CIs for the least‐squares mean differences between omarigliptin 175 mg and placebo in QTcP interval change from baseline were all < 10 milliseconds at every postdose point on day 2. The upper bounds of the 90%CIs for the differences (omarigliptin‐placebo) in QTcP change from baseline for omarigliptin 175 mg were < 10 milliseconds at all postdose times on day 2. In conclusion, a supratherapeutic dose of omarigliptin does not prolong the QTcP interval to a clinically meaningful degree relative to placebo, confirming the results of the earlier concentration‐QTc analysis.