Open AccessSuccessful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection
Author(s) -
Vuorenoja Susanna,
Vettenranta Kim,
Lohi Olli
Publication year - 2022
Publication title -
cancer reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 5
ISSN - 2573-8348
DOI - 10.1002/cnr2.1663
Subject(s) - medicine , myeloid leukemia , anticipation (artificial intelligence) , hematopoietic stem cell transplantation , disease , stem cell , transplantation , leukemia , immunology , artificial intelligence , biology , computer science , genetics
Background Chronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. Case We describe an 8‐year‐old patient with CML treated with two different TKIs before proceeding to allogeneic HSCT. Despite successful engraftment, prompt rejection of the graft was followed by autologous reconstitution. TKI therapy was reintroduced post‐rejection in anticipation of relapse but shortly discontinued due to low white blood cell and neutrophil counts. The patient has remained disease‐free over 5 years after graft rejection and without further therapy. Conclusion This case suggests that even a short antileukemic effect by an allogeneic transplant may succeed in eradicating CML.