Open AccessFacial disfigurement due to olfactory neuroblastoma: beauty regained with chemotherapy
Author(s) -
Kumar Parmod,
Sundriyal Deepak,
Bhandari Rekha,
Singh Abhijeet,
Jat Bhinyaram,
Sehrawat Amit
Publication year - 2021
Publication title -
cancer reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 5
ISSN - 2573-8348
DOI - 10.1002/cnr2.1303
Subject(s) - esthesioneuroblastoma , disfigurement , medicine , chemotherapy , malignancy , neuroblastoma , surgery , radiation therapy , oncology , biology , genetics , cell culture
Background Olfactory neuroblastoma (ONB) is a sinonasal malignancy seldom seen in clinical practice. It is also known by various other names like esthesioneuroblastoma, esthesioneuroepithelioma, esthesioneurocytoma, and esthesioneuroma. Surgery and radiation therapy are considered as standard treatment modalities for ONB; however, the role of chemotherapy is not well established. Aims We aim to define the role of chemotherapy in the neoadjuvant setting in a case of ONB. Methods and Results We report a young female patient presenting with a naso‐facial swelling causing facial disfigurement, proptosis, decreased visual acuity, and poor performance status. She was diagnosed with advanced‐stage ONB. Prompt administration of chemotherapy led to the improvement in the symptoms and rapid regression of the tumor mass. Later on, the tumor mass was excised completely without any neurological deficit. Conclusion This report justifies the role of neoadjuvant chemotherapy in the management of ONB.