Open AccessParaneoplastic vasculitis in patients with metastatic renal cell carcinoma
Author(s) -
Tsimafeyeu Ilya,
Leonenko Valentina,
Kuznetsov Vladimir,
Semenkova Evgenia,
Bondarenko Anastasia,
Demidov Lev
Publication year - 2019
Publication title -
cancer reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 5
ISSN - 2573-8348
DOI - 10.1002/cnr2.1142
Subject(s) - medicine , renal cell carcinoma , skin biopsy , vasculitis , rash , biopsy , thrombosis , dermatology , cancer , incidence (geometry) , pathology , disease , physics , optics
Abstract Background A paraneoplastic syndrome is observed in 5% to 10% of cancer patients. Paraneoplastic vasculitis (PV) in metastatic renal cell carcinoma (mRCC) patients has been poorly investigated. Aims In our case series study, we evaluated the incidence and development of PV in patients with mRCC. Methods and results Patients were required to have previously untreated clear‐cell or papillary mRCC and no evidence of autoimmune diseases or venous thrombosis in history. Patients had a careful examination including Doppler ultrasonography of the blood vessels and skin punch biopsy in the presence of suspicious skin rash. Sixteen (8.2%) of 196 patients were diagnosed with PV, which was manifested clinically by leukocytoclastic vasculitis on the lower extremities. Skin biopsy confirmed vasculitis. Progression‐free survival and overall survival were significantly better in patients without PV. Conclusions PV is not rare paraneoplastic syndrome in mRCC. Leukocytoclastic vasculitis was the most common type of PV in this study.