Open AccessHow do cancer cells replenish their fuel supply?
Author(s) -
Alameddine Abdallah K.,
Conlin Frederick T.,
Binnall Brian J.,
Alameddine Yvonne A.,
Alameddine Khaled O.
Publication year - 2018
Publication title -
cancer reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.261
H-Index - 5
ISSN - 2573-8348
DOI - 10.1002/cnr2.1003
Subject(s) - cancer , carcinogenesis , cancer cell , autophagy , biology , phenotype , metabolic pathway , cell metabolism , bioinformatics , computational biology , metabolism , cancer research , neuroscience , biochemistry , genetics , gene , apoptosis
Abstract Background Multiple genetic changes, availability of cellular nutrients and metabolic alterations play a pivotal role in oncogenesis Aims We focus on cancer cell's metabolic properties, and we outline the cross talks between cellular oncogenic growth pathways in cancer metabolism. The review also provides a synopsis of the relevant cancer drugs targeting metabolic activities that are at various stages of clinical development. Methods We review literature published within the last decade to include select articles that have highlighted energy metabolism crucial to the development of cancer phenotypes. Results Cancer cells maintain their potent metabolism and keep a balanced redox status by enhancing glycolysis and autophagy and rerouting Krebs cycle intermediates and products of β‐oxydation. Conclusions The processes underlying cancer pathogenesis are extremely complex and remain elusive. The new field of systems biology provides a mathematical framework in which these homeostatic dysregulation principles may be examined for better understanding of cancer phenotypes. Knowledge of key players in cancer‐related metabolic reprograming may pave the way for new therapeutic metabolism–targeted drugs and ultimately improve patient care.