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Chemical Stability of Metal‐organic Frameworks for Applications in Drug Delivery
Author(s) -
Bunzen Hana
Publication year - 2021
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202100226
Subject(s) - nanocarriers , drug delivery , nanotechnology , surface modification , metal organic framework , materials science , nanoparticle , chemical stability , drug , drug carrier , porosity , chemical engineering , chemistry , organic chemistry , pharmacology , engineering , medicine , adsorption , composite material
Structural variety, tunable porosity and opportunities for functionalization make metal‐organic frameworks (MOFs) promising materials for applications in medicine as drug delivery systems. In this minireview, an overview of chemical stability of MOF nanocarriers at simulated body conditions is presented. Parameters such as a choice of buffer, pH value, nanoparticle size or surface modification are discussed, as well as analytical methods and approaches suitable to determine the material stability. Last but not least, examples of tuning and improving the chemical stability of MOF nanoparticles for solution‐based drug delivery (oral and intravenous) are presented and examples of MOFs as pH‐responsive drug nanocarriers are given.