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Cover Feature: Polydopamine‐Mediated Surface Functionalization of Exosomes (ChemNanoMat 6/2021)
Author(s) -
Wang Chenyu,
Kimura Kenta,
Li Jincai,
Richardson Joseph J.,
Naito Mitsuru,
Miyata Kanjiro,
Ichiki Takanori,
Ejima Hirotaka
Publication year - 2021
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202100154
Subject(s) - surface modification , coating , microvesicles , covalent bond , pegylation , nanotechnology , chemistry , polymer , reagent , bioconjugation , materials science , combinatorial chemistry , organic chemistry , biochemistry , microrna , polyethylene glycol , gene
Exosomes were non‐covalently functionalized using the self‐polymerization of dopamine and subsequent PEGylation via Thiol‐Michael addition. This rapid and versatile exosome coating method improved the colloidal stability of exosomes and endowed them with tunable fluorescence and coating thickness. Collectively, this aggregation‐free non‐covalent coating approach expands the potential of exosomes in various applications without requiring complex equipment or reagents. More information can be found in the Communication by Hirotaka Ejima et al.