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Polydopamine‐Mediated Surface Functionalization of Exosomes
Author(s) -
Wang Chenyu,
Kimura Kenta,
Li Jincai,
Richardson Joseph J.,
Naito Mitsuru,
Miyata Kanjiro,
Ichiki Takanori,
Ejima Hirotaka
Publication year - 2021
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202100078
Subject(s) - microvesicles , surface modification , extracellular vesicles , nanotechnology , coating , scope (computer science) , materials science , chemistry , computer science , microbiology and biotechnology , biology , microrna , biochemistry , gene , programming language
Exosomes are cell‐derived extracellular vesicles that hold promise for diagnosis and therapy. The surface characteristics of exosomes dictate their biological fate and are therefore important for various applications, however surface modification strategies are generally either limited in scope or require complex equipment or experimental procedures. Herein, we employ a simple and fast method to control the surface properties of exosomes via polydopamine coating. Specifically, the polydopamine coating allowed for tailorable functionalization via secondary reactions, which opens exciting avenues for the application of exosomes.