z-logo
Premium
Sodium Monododecylphosphate Vesicles Formed in Alcohol/Water Mixtures
Author(s) -
Gao Meihua,
Yao Zhiyin,
Du Na,
Deng Quanhua,
Liu Lijing,
Liu Jianqiang,
Hou Wanguo
Publication year - 2021
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202100013
Subject(s) - vesicle , chemistry , amphiphile , solubility , chemical engineering , molecule , alcohol , aqueous solution , phase (matter) , biophysics , organic chemistry , membrane , polymer , biochemistry , engineering , copolymer , biology
Sodium monododecylphosphate (SDP), a typical single‐chain amphiphile (SCA), exhibits extremely low solubility in water, which limits the investigation on its aggregation behavior. In the current work, we introduced short‐ and medium‐chain alcohols into the SDP‐water system to improve its solubility. An isotropic phase was found to be formed in the presence of alcohol with a suitable dielectric constant (11–25) or alkyl chain (2–7 carbons). In addition, vesicular, dendritic, and micellar structures were identified in the isotropic phase, depending on the composition of the SDP/alcohol/H 2 O ternary systems. The structure, stability, permeability, and formation mechanism of the vesicles formed in the SDP/ n ‐pentanol (NPT)/H 2 O system were investigated. The vesicles have a unilamellar structure, with size‐selective permeability. They show remarkable stability upon long‐term storage, exposure to high temperature, and freeze‐thawing cycles, but are metastable in thermodynamics. The hydrogen bonding between SDP molecules plays an important role in the formation of vesicles. Furthermore, the SDP/NPT/H 2 O vesicles were used to construct three spatially segregated enzyme‐loaded compartments to support a cascade enzyme reaction. The chemical signal transduction among the enzyme‐loaded vesicles was achieved. This study provides a deeper understanding of the features of SDP vesicles and demonstrates their potential applications such as in biomembrane mimicking and micro‐reactors.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here