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Fluorescence Turn‐off Magnetic Fluorinated Graphene Composite with High NIR Absorption for Targeted Drug Delivery
Author(s) -
Wang Dandan,
Zhang Yuanyuan,
Zhai Mingzhu,
Huang Yan,
Li Hui,
Liu Xicheng,
Gong Peiwei,
Liu Zhe,
You Jinmao
Publication year - 2021
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202000539
Subject(s) - graphene , materials science , composite number , photothermal therapy , hyaluronic acid , absorption (acoustics) , drug delivery , magnetism , fluorescence , nanotechnology , nanoparticle , dispersity , magnetic nanoparticles , combinatorial chemistry , chemical engineering , chemistry , composite material , polymer chemistry , optics , medicine , engineering , quantum mechanics , anatomy , physics
Although fluorinated graphene/Fe 3 O 4 composites exhibit a unique structure and chemical surface, and thus hold great potential in many fields, their effective synthesis has remained a headache because of poor dispersity and easy aggregation behavior. Herein, we report a novel method to prepare hyaluronic acid (HA)‐modified fluorinated graphene with a well‐defined structure and good solubility in various media, and this then allowed us for the first time to controllably deposit magnetic Fe 3 O 4 nanoparticles onto the sheets with designed ratio and contents. This strategy further guaranteed a multifunctional composite that possessed HA and magnetism‐induced dual‐targeting effect towards cancer cells and high near‐infrared absorption for photothermal therapy (PTT). Moreover, this composite also showed an effective turn‐off fluorescence effect for the anticancer drug doxorubicin, allowing us to visually monitor the drug loading procedure. Anticancer experiments indicated that such a successful combination of PTT and chemotherapy with special selectivity toward cancer cells exhibited a much better therapeutic effect than single therapy.