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Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer
Author(s) -
Zhang Xiaoqin,
Zu Hongru,
Guo Yanxian,
Liu Qingqing,
Liu Zhiming,
Hu Chaofan
Publication year - 2020
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202000311
Subject(s) - photothermal therapy , materials science , nanomaterials , surface plasmon resonance , absorption (acoustics) , nanoparticle , amorphous solid , nanotechnology , molybdenum , chemical engineering , chemistry , organic chemistry , engineering , metallurgy , composite material
Semiconductor nanocrystals showing surface plasmonic absorption features can be used as prospective substitutes for noble metallic nanoparticles. Herein, a creative one‐pot hydrothermal route without template is used to synthesize plasmonic oxygen deficiency molybdenum oxide (MoO 3‐x ) nanoparticles. The morphologies of as‐prepared MoO 3‐x nanomaterials arranged from amorphous to crystalline with the reaction temperature varied from 160 °C, 180 °C to 200 °C, namely MoO 3‐x quantum dots (QDs), MoO 3‐x nanosheets, and MoO 2 nanospheres. Simultaneously, in the near‐infrared region (NIR), MoO 3‐x nanomaterials exhibit gradually enhanced localized surface plasmon resonance (LSPR) absorption, of which MoO 2 nanospheres exhibit intense NIR absorption with a photothermal conversion efficiency up to 72.5% under 808 nm NIR laser irradiation. Moreover, the toxicity and cancer therapy efficacy of MoO 2 nanospheres have been systematically assessed in vitro and in vivo , respectively. The results revealed that MoO 2 nanospheres exhibit low toxicity and high therapeutic efficiency, making it an promising and effective photothermal agent in photothermal therapy