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H 2 O 2 ‐Responsive Nanogel for Enhancing Chemodynamic Therapy
Author(s) -
Yang Yuling,
Lin Yuhong,
Jiang Lili,
Han Wen,
Wang Min,
Lu Chunhua,
Yang Huanghao
Publication year - 2020
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202000128
Subject(s) - nanogel , hydrogen peroxide , chemistry , tumor microenvironment , reactive oxygen species , biocompatibility , cancer cell , in vivo , glucose oxidase , fenton reaction , cytotoxicity , hydroxyl radical , apoptosis , cancer research , biophysics , radical , biochemistry , in vitro , drug delivery , cancer , tumor cells , biology , organic chemistry , genetics , microbiology and biotechnology , biosensor
As a typical chemodynamic therapy (CDT), the Fenton reaction holds great promise in cancer therapy for its effective generation of the cytotoxic hydroxyl radical ( . OH) in situ which induces cancer cell apoptosis. However, the tumor microenvironment is insufficient to meet the optimal conditions for Fenton reaction, which greatly reduces the rate of Fenton reaction and the therapeutic effect of CDT, thereby hindering its application in cancer therapy. Herein, a novel biocompatible nanogel comprised of ferroferric oxide modified β‐cyclodextrin (Fe 3 O 4 @β‐CD), glucose oxidase (GO X ), and ferrocene (Fc) was fabricated using the host‐guest self‐assembly method for synergistic tumor therapy (Fe 3 O 4 −GO X nanogel, FGgel). In the tumor microenvironment, the intratumoral hydrogen peroxide (H 2 O 2 ) could oxidize Fc, leading to the disintegration of the FGgel and the release of GO X . Subsequently, the released GO X could catalyze glucose to produce gluconic acid and promote the production of H 2 O 2 . Meanwhile, in acidic conditions, F 3 O 4 served as the Fenton reagent to convert excessive H 2 O 2 into highly toxic . OH which finally induces tumor cell apoptosis. Extensive in vitro and in vivo studies have confirmed that FGgel can effectively inhibit tumor cell growth with high tumor specificity and good biocompatibility. The excellent anticancer efficiency of FGgel indicates that it is an ideal H 2 O 2 ‐activated nanosystem. As an excellent platform to harness the highly toxic reactive oxygen species in nanomedicine for specific cancer therapy, this strategy may open new doors for further development of progressive therapeutic systems.