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Mucopenetrating Zwitterionic Micelles
Author(s) -
Taipaleenmäki Essi,
Brodszkij Edit,
Städler Brigitte
Publication year - 2020
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.202000050
Subject(s) - micelle , amphiphile , phosphorylcholine , copolymer , chemistry , cytotoxicity , dispersity , mucus , biophysics , polymer chemistry , organic chemistry , biochemistry , aqueous solution , in vitro , biology , ecology , polymer
The intestinal mucus layer remains a challenging biological barrier to cross for nanoformulations. We report the assembly of zwitterionic micelles with 2‐methacryloyloxyethyl phosphorylcholine as the zwitterionic entity in the corona‐forming part of the amphiphilic block copolymers. These ca. 200 nm micelles do not have inherent cytotoxicity in Caco‐2 cells for a 24 h incubation time. The time‐resolved crossing of the mucus layer in Caco‐2/HT29‐MTX‐E12 co‐cultures of these spherical micelles with narrow polydispersity is shown.