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Mitochondria‐Targeted Water‐Soluble Organic Nanoparticles of Chlorin Derivatives for Biocompatible Photodynamic Therapy
Author(s) -
Liu Yang,
Lee Tae Heon,
Lee Sang Hyeob,
Li Jiazhu,
Lee Woo Kyoung,
Yoon Il
Publication year - 2020
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201900759
Subject(s) - photodynamic therapy , hela , chemistry , solubility , mitochondrion , nanoparticle , precipitation , biocompatible material , solvent , water soluble , combinatorial chemistry , nuclear chemistry , materials science , organic chemistry , nanotechnology , biochemistry , in vitro , biomedical engineering , medicine , physics , meteorology
Water‐soluble organic nanoparticles (WSONs) were prepared by a very simple co‐precipitation method through nanoprecipitation (solvent‐exchange) from THF to water. WSONs are 87–112 nm in size with good water solubility and high water stability for more than a month. WSONs accumulated in mitochondria and induced mitochondria‐mediated apoptosis through photodynamic activity against HeLa cells. More information can be found in the Full Paper by Woo Kyoung Lee, Il Yoon et al.