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Synthesis of Plasmin‐Loaded Fe 3 O 4 @CaCO 3 Nanoparticles: Towards Next‐Generation Thrombolytic Drugs
Author(s) -
Serov Nikita,
Prilepskii Artur,
Sokolov Alexey,
Vinogradov Vladimir
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201900359
Subject(s) - plasmin , serine protease , fibrin , nanoparticle , chemistry , protease , cleavage (geology) , nanotechnology , materials science , enzyme , biochemistry , medicine , immunology , fracture (geology) , composite material
Abstract A major obstacle in the development of the next‐generation of thrombolytic drugs has been the fact that plasmin – a serine protease that dissolves fibrin in blood clots – despite being the only enzyme suitable for the clot cleavage, is still not used in practice due to its rapid inactivation. Here we point to a potential solution to this problem by developing a magnetically controlled system for targeted delivery and recrystallization‐driven release of plasmin showing therapeutic potential.