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Front Cover: Organosilica Nanoparticles for Gemcitabine Monophosphate Delivery in Cancer Cells (ChemNanoMat 7/2019)
Author(s) -
Daurat Morgane,
Rahmani Saher,
Bouchal Roza,
Akrout Alia,
Budimir Jelena,
Nguyen Christophe,
Charnay Clarence,
Guari Yannick,
Richeter Sébastien,
Raehm Laurence,
Bettache Nadir,
GaryBobo Magali,
Durand JeanOlivier,
Hesemann Peter
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201900267
Subject(s) - gemcitabine , nanomedicine , nanoparticle , cancer cell , nanotechnology , drug delivery , cancer , tumor cells , chemistry , cancer research , materials science , medicine
Two kinds of organosilica nanoparticles based on ionosilicas or neutral tertiary amino compounds have been loaded with gemcitabine monophosphate and are able to deliver the drug in cancer cells due to phosphate exchange or pH stimulus. Both nanoparticles are endocytosed in cancer cells, as monitored by fluorescence microscopy, and are very efficient, leading to 60% cancer cell death. These nanoparticles are therefore promising vectors for nanomedicine applications against tumors. More information can be found in the Full Paper by Magali Gary‐Bobo, Jean‐Olivier Durand, Peter Hesemann et al. on page 888 in Issue 7, 2019 (DOI: 10.1002/cnma.201900202).