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Spot‐on SERS Detection of Biomolecules with Laser‐Patterned Dot Arrays of Assembled Silver Nanowires
Author(s) -
Banchelli Martina,
Amicucci Chiara,
Ruggiero Emmanuel,
D'Andrea Cristiano,
Cottat Maximilien,
Ciofini Daniele,
Osticioli Iacopo,
Ghini Giacomo,
Siano Salvatore,
Pini Roberto,
de Angelis Marella,
Matteini Paolo
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201900035
Subject(s) - nanotechnology , analyte , biomolecule , materials science , substrate (aquarium) , characterization (materials science) , fabrication , nanowire , chemistry , chromatography , medicine , oceanography , alternative medicine , pathology , geology
Unique characteristics of SERS including the possibility to reveal the compositional and structural content of trace amounts of biological samples without any pre‐treatment, depict this technique as a promising label‐free alternative to standard analytical methods. Despite significant advancements, current SERS substrates for biomolecule detection suffer from a number of issues still impeding their routine usage and commercial exploitation, including complex and expensive fabrication procedures and scarce standardization perspectives. Herein a combined bottom up/top down scheme based on flow‐through method plus laser patterning is proposed to prepare dot arrays of silver nanowires on a hydrophobic substrate for catching the analyte content from a minute amount of liquid sample and its rapid SERS inspection. As a consequence, a simple spot‐on analysis specifically adapted for reliable identification and characterization of molecules of biomedical interest is made possible. Our attempt may represent a concrete chance for progressing SERS toward widespread commercially viable sensing applications including diagnostics at the point‐of‐need settings and on‐site analyses.