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Black Phosphorus Nanomaterials Regulate the Aggregation of Amyloid‐β
Author(s) -
Lim YehJun,
Zhou Wenhua,
Li Gao,
Hu ZhiWen,
Hong Liu,
Yu XueFeng,
Li YanMei
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201900007
Subject(s) - nanomaterials , black phosphorus , amyloidosis , amyloid (mycology) , amyloid fibril , chemistry , phosphorus , adsorption , nanotechnology , materials science , amyloid β , disease , medicine , organic chemistry , inorganic chemistry , optoelectronics
Aggregation of amyloid‐β (Aβ) plays important roles in the progression of Alzheimer's disease (AD), and various carbon‐based nanomaterials have been shown to significantly inhibit aggregation of Aβ. A new member of the family of two‐dimensional (2D) nanomaterials, black phosphorus (BP), has been successfully prepared. Compared to other nanomaterials, BP has a higher surface‐to‐volume ratio, so it has strong adsorption ability for Aβ, and can thereby regulate the aggregation of Aβ. Herein, black phosphorus (BP) nanomaterials are proposed to regulate the aggregation of Aβ for the first time, and the corresponding mechanism is clarified. This work provides new insight into the development of BP‐based strategies to prevent amyloidosis.