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Gold Nanorattles with Intense Raman In Silica Nanoparticles (Nano‐IRIS) as Multimodal System for Imaging and Therapy
Author(s) -
Ahlawat Monika,
Sarkar Ankita,
Roy Shounak,
Jaiswal Amit
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201800648
Subject(s) - materials science , colloidal gold , mesoporous silica , nanotechnology , plasmon , plasmonic nanoparticles , nanoparticle , coating , drug delivery , fluorescence , raman spectroscopy , mesoporous material , chemistry , optoelectronics , optics , biochemistry , physics , catalysis
Hybrid colloids consisting of silica coated plasmonic core‐shell metal nanoparticles have driven progress in plethora of applications and are under intense investigation in diverse fields of research. In this regard, we have designed a multifunctional nanocomposite consisting of 1,4‐benzenedithiol (BDT) tagged gold nanorattles (Au‐NRT) as core embedded within a solid silica shell with an additional mesoporous silica shell coating forming an “IRIS” like morphology, referred to as Nano‐IRIS. The nanorattle structure with a solid gold octahedron core and porous cubic gold shell serves as an excellent SERS probe due to the presence of intrinsic electromagnetic (EM) hot‐spots. The intelligent design of incorporating a solid SiO 2 layer in the core‐shell Nano‐IRIS structure helped in incorporating two different imaging functionalities, namely SERS and fluorescence‐based bioimaging into a single nanoplatform, thereby imparting a multimodal imaging attribute to Nano‐IRIS. The solid SiO 2 layer not only helped in keeping the Raman reporter intact in the pores of AuNRT but also maintained the distance between the gold surface and the fluorescent drug Doxorubicin (DOX) encapsulated inside the mSiO 2 layer to achieve fluorescence imaging without quenching. Additionally, Nano‐IRIS also emerged as a drug delivery system demonstrating highly efficient concentration dependent chemotherapy via ROS production and oxidative DNA damage.