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β‐Cyclodextrin‐Decorated Carbon Dots Serve as Nanocarriers for Targeted Drug Delivery and Controlled Release
Author(s) -
Yang Ting,
Huang JingLi,
Wang YiTing,
Zheng AnQi,
Shu Yang,
Wang JianHua
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201800528
Subject(s) - nanocarriers , drug delivery , förster resonance energy transfer , nanomedicine , doxorubicin , folate receptor , chemistry , targeted drug delivery , conjugate , drug , nanotechnology , biophysics , endocytosis , combinatorial chemistry , fluorescence , materials science , pharmacology , cancer cell , biochemistry , nanoparticle , medicine , receptor , cancer , biology , mathematics , mathematical analysis , quantum mechanics , physics , surgery , chemotherapy
A novel nanocarrier for targeted delivery of anti‐cancer drug doxorubicin (DOX) was fabricated with carbon dots (CDots) as the matrix. Fluorescent CDots capable of targeting folate receptor‐positive cells first conjugate with boric acid and then couple with β‐CD to produce the nanocarrier β‐CD/CDots. DOX was encapsulated into the cavity of β‐CD providing a maximum loading ratio of 27.3% at pH 7.4. Benefiting from pH‐sensitive dissociation of DOX/β‐CD inclusion complex and the cleavage of the bonding between boric acid and β‐CD, pH‐triggered release of drugs was realized, with an 82% release of the loaded drug at pH 5.0. Meanwhile, the fluorescence resonance energy transfer (FRET) occurs between CDots (donor) and DOX (acceptor), which may potentially facilitate monitoring/tracing of the drug delivery process. In vitro results further demonstrated the targeting capability of the nanocarrier towards folate receptor‐positive cells. Moreover, confocal microscopy results, in accordance with that of flow cytometry analysis, confirmed the efficient intracellular uptake of DOX‐β‐CD/CDots and sustained release of DOX. This makes DOX‐β‐CD/CDots promising as biocompatible and multifunctional nanomedicine for targeted delivery, controlled release and real time monitoring/tracing of drugs.