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Virus‐Based Nanomotors for Cargo Delivery
Author(s) -
TejedaRodríguez José A.,
Núñez Alfredo,
Soto Fernando,
GarcíaGradilla Víctor,
CadenaNava Rubén,
Wang Joseph,
VazquezDuhalt Rafael
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201800403
Subject(s) - virus , nanotechnology , drug delivery , virology , hydrogen peroxide , surface modification , materials science , chemistry , biophysics , microbiology and biotechnology , biology , biochemistry
Abstract Self‐propelled nanomotors based on virus structure were designed, fabricated and characterized. Capsids from plant virus were covered on one hemisphere with platinum layer to promote motion in the presence of hydrogen peroxide. The Janus viral nanomotors (JVNs) with 25–30 nm diameter from brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) showed motion speeds of up to 9 μm/sec, depending of the peroxide fuel concentration in the medium. The JVNs can carry and deliver the chemo‐therapeutic drug Tamoxifen, and they are able to internalize into breast tumor cells without any functionalization. The therapeutic payload is released by a pH‐driven delivery action of the nanomotor. Here, the first proof of concept of a self‐propelled virus‐like nanoparticle is demonstrated. The attractive capabilities of nanomotors based on virus‐like nanoparticles (VLPs) pave the way to diverse biomedical applications.