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Fluorescent Inorganic‐Organic Hybrid Nanoparticles
Author(s) -
Neumeier B. Lilli,
Khorenko Mikhail,
Alves Frauke,
Goldmann Oliver,
Napp Joanna,
Schepers Ute,
Reichardt Holger M.,
Feldmann Claus
Publication year - 2019
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201800310
Subject(s) - fluorescence , nanomaterials , nanoparticle , lanthanide , singlet oxygen , chemistry , aqueous solution , nuclear chemistry , drug delivery , hybrid material , materials science , nanotechnology , oxygen , organic chemistry , ion , physics , quantum mechanics
Inorganic‐organic hybrid nanoparticles (IOH‐NPs) with a general composition [ZrO] 2+ [R Dye OPO 3 ] 2− , [Ln] 3+ n/3 [R Dye (SO 3 ) n ] n− , [Ln(OH)] 2+ n/2 [R Dye (SO 3 ) n ] n− , or [LnO] + n [R Dye (SO 3 ) n ] n− (Ln: lanthanide) are a novel class of nanomaterials for fluorescence detection and optical imaging. IOH‐NPs are characterized by an extremely high load of the fluorescent dye (70–85 wt‐%), high photochemical stability, straightforward aqueous synthesis, low material complexity, intense emission and high cell uptake at low toxicity. Besides full‐color emission, IOH‐NPs are suitable for multimodal imaging, singlet‐oxygen generation as well as drug delivery and drug release. This focus review presents the material concept of the IOH‐NPs as well as their synthesis and characterization. Their characteristic features are illustrated by selected in vitro and in vivo studies to initiate application in biology and medicine.