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An Asymmetrical Cyanine Dye Nanoparticles for Small Vessel Photoacoustic Imaging In Vivo
Author(s) -
Li Yunzheng,
Xiong Jialiang,
Shao Zixing,
Ai Yongjian,
Hua Ruimao,
Luo Guoan,
Liang Qionglin
Publication year - 2018
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201800170
Subject(s) - cyanine , photoacoustic imaging in biomedicine , in vivo , nanoparticle , tail vein , absorption (acoustics) , materials science , matrix (chemical analysis) , biophysics , chemistry , biomedical engineering , nanotechnology , optics , fluorescence , composite material , medicine , physics , microbiology and biotechnology , biology
A novel asymmetrical cyanine dye (TR) with NIR absorption at 970 nm was synthesized and applied in photoacoustic imaging (PAI) in vivo for the first time. The advantages of asymmetrical structure in PAI was demonstrated with DFT calculation and verified by related experiments. BSA was selected as the matrix to encapsulate TR‐BSA nanoparticles (TR‐NPs) which was investigated as a PAI agent. Exceptional performance of TR‐NPs was shown in Balb/c rats caudal vein model; the details could be clearly displayed and identified at a 0.1 mm scale.