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DNA‐Mediated Assembly of Gold Nanoparticles and Applications in Bioanalysis
Author(s) -
Xue Jing,
Chen Feng,
Bai Min,
Yu Xu,
Wei Jing,
Huang Ping,
Zhao Yongxi
Publication year - 2017
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201700177
Subject(s) - bioanalysis , nanotechnology , colloidal gold , dna , nanoparticle , nucleic acid , biosensor , base pair , aptamer , template , materials science , chemistry , biology , microbiology and biotechnology , biochemistry
DNA‐mediated gold nanoparticles (AuNPs) assembly has drawn great attention due to the controllable parameters and properties. In general, DNA sequences working as linkers or templates precisely control the assembly of AuNPs through the Watson–Crick base pairing. Diverse assembly structures show great potential in bioanalysis due to the unique optical characteristics, which can be tuned by the shape, size, composition, particles interactive status and the dielectric constant of the surrounding medium of AuNPs. They exhibit excellent performances for the detection of nucleic acids, proteins, small molecules and other biomarkers. In this review, we present a general overview of the construction of DNA‐mediated AuNP assemblies and the recent advances of these assemblies as high‐performance biosensors. Future directions and major challenges in bioanalysis are also discussed.